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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
42.42
Human Site:
Y253
Identified Species:
58.33
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
Y253
H
D
E
G
M
L
E
Y
L
E
D
I
I
G
C
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
Y253
H
D
E
G
M
L
E
Y
L
E
D
I
I
G
C
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
Y252
H
D
E
G
M
L
E
Y
L
E
D
I
I
G
C
Dog
Lupus familis
XP_535848
1288
147094
Y253
H
D
E
G
M
L
E
Y
L
E
D
I
I
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
Y251
H
D
E
G
M
L
E
Y
L
E
D
I
I
G
C
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
L238
N
E
V
E
I
E
K
L
N
K
E
L
A
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
E157
N
K
I
T
K
F
I
E
E
N
K
E
K
F
T
Chicken
Gallus gallus
NP_989849
1274
145838
K264
N
R
V
K
M
V
E
K
E
K
D
A
L
E
G
Frog
Xenopus laevis
P50532
1290
146971
Y247
H
D
E
G
M
L
E
Y
L
E
D
I
I
G
S
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
Y252
H
D
E
G
M
L
E
Y
L
E
D
I
I
G
S
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
Y249
H
D
E
G
M
L
E
Y
L
E
D
I
I
G
S
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
E428
N
E
R
K
K
T
E
E
L
Q
C
S
I
D
E
Honey Bee
Apis mellifera
XP_396862
1282
148175
L238
Y
K
E
P
L
E
K
L
S
N
K
I
E
L
L
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
Y259
S
E
T
G
M
V
E
Y
L
E
D
I
I
G
T
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
Y274
H
E
E
G
M
L
E
Y
L
E
D
I
I
G
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
E246
N
L
E
G
L
K
D
E
A
E
T
Y
M
L
K
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
Y326
S
D
D
G
L
L
E
Y
L
E
D
I
I
G
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
93.3
N.A.
100
0
N.A.
0
20
93.3
93.3
93.3
20
13.3
66.6
86.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
46.6
N.A.
6.6
46.6
93.3
93.3
93.3
40
33.3
80
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
73.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
6
0
0
6
6
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
24
% C
% Asp:
0
53
6
0
0
0
6
0
0
0
71
0
0
6
0
% D
% Glu:
0
24
65
6
0
12
77
18
12
71
6
6
6
6
6
% E
% Phe:
0
0
0
0
0
6
0
0
0
0
0
0
0
6
0
% F
% Gly:
0
0
0
71
0
0
0
0
0
0
0
0
0
65
6
% G
% His:
53
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
6
0
6
0
6
0
0
0
0
71
71
0
0
% I
% Lys:
0
12
0
12
12
6
12
6
0
12
12
0
6
0
12
% K
% Leu:
0
6
0
0
18
59
0
12
71
0
0
6
6
12
6
% L
% Met:
0
0
0
0
65
0
0
0
0
0
0
0
6
0
0
% M
% Asn:
30
0
0
0
0
0
0
0
6
12
0
0
0
0
0
% N
% Pro:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
6
0
0
0
0
0
% Q
% Arg:
0
6
6
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
12
0
0
0
0
0
0
0
6
0
0
6
0
6
30
% S
% Thr:
0
0
6
6
0
6
0
0
0
0
6
0
0
0
18
% T
% Val:
0
0
12
0
0
12
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
0
0
0
0
0
0
65
0
0
0
6
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _